Enzymatic semisynthesis of human insulin.
نویسندگان
چکیده
منابع مشابه
Semisynthesis of Human Insulin Utilizing Chemically Modified Carboxypeptidase
It has previously been demonstrated that the C-terminal alanyl residue in the B-chain of porcine insulin can be exchanged with a threonyl residue in a carboxypeptidase Y catalyzed transpeptidation reaction using threonine amide as nucleophile. However, with this procedure the transpeptidation product, human insulin amide, was obtained in relatively low yields. In the present paper it is demonst...
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ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1986
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.60.841